全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR10935G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality XRCC1 antibody (Center).
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分子量 |
69477 Da
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細胞定位 |
Antigen Cellular Localization:
Nucleus. Note=Accumulates at sites of DNA damage
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
407-435 aa
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靶點 |
This XRCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the Central region of human XRCC1.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
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總結(jié) |
The protein encoded by this gene is involved in theefficient repair of DNA single-strand breaks formed by exposure toionizing radiation and alkylating agents. This protein interactswith DNA ligase III, polymerase beta and poly (ADP-ribose)polymerase to participate in the base excision repair pathway. Itmay play a role in DNA processing during meiogenesis andrecombination in germ cells. A rare microsatellite polymorphism inthis gene is associated with cancer in patients of varyingradiosensitivity.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC-P, FC, IF, E
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稀釋方法 |
IF~~1:25
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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別名 |
DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1
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圖像 |
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說明書 |
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數(shù)量 |
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