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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR02432G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RIPK3 / RIP3 Antibody (aa480-530).
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分子量 |
57kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytosol. Cell membrane Mitochondrion
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
A portion of amino acids 480-518 of human RIP3
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通用名 |
RIP3
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基因ID |
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UniProt ID |
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功能 |
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
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總結(jié) |
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P
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稀釋方法 |
IHC-P (10 μg/ml), WB (1-3 μg/ml),
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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